The brain is a black box. A complex circuitry of neurons fires information through channels, much like the inner workings of a computer chip. But while computer processors are regimented with the deft economy of an assembly line, neural circuits are impenetrable masses. Think tumbleweed.

Researchers in Harvard Medical School’s Department of Neurobiology have developed a technique for unraveling these masses. Through a combination of microscopy platforms, researchers can crawl through the individual connections composing a neural network, much as Google crawls web links.

 “The questions that such a technique enables us to address are too numerous even to list,” said Clay Reid, HMS professor of neurobiology and senior author
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